The family correspondence of Richard and Sarah Franklin Bache on a variety of topics including references to Benjamin Franklin and his estate. There is also a family genealogy.

The Scaliger Family Papers, when taken together, trace the history of a noble family that was originally from Italy but lived primarily in Agen, France from the mid-1500s through the mid-1800s. Beginning with the patriarch, Julius Caesar Scaliger (1484-1558), a celebrated Italian scholar and physician, the members of the Scaliger family upheld an illustrious reputation over the centuries as scholars, military leaders, and noblemen. Throughout their family's history, the Scaligers maintained that they were descended from the Della Scallas, Princes of Verona. It is as a result of the necessity to defend this claim as well as later attempts to prove their ties to their noble heritage that this collection of documents has remained so well intact. The Scaliger Family Papers is a collection that encompasses several different kinds of documents that span from 1539 to 1862 including letters, genealogical material, works by members of the Scaliger family, as well as military, legal, and financial documents.

The collection includes letters between Hutchinson and his uncle Israel Pemberton, written while Hutchinson was a student of medicine in London. There are also 12 tickets of admission to medical lectures in Philadelphia and London, including one given by William Hunter, and 3 unused cards of admission to Hutchinson's own lectures. Miscellaneous items include Hutchinson's marriage certificate; genealogical data on the Hutchinson, Hare, and Pemberton families; and stock certificates, 1857-1872, of the McKean and Elk Land and Improvement Company. Materials dated post-1793 are to and from Hutchinson family members.

One of the oldest houses in Philadelphia, Wyck is now a non-profit museum listed on the National Register of Historic Places. Nine generations of the Jansen-Wistar-Haines family owned the Wyck property from 1690 until 1973. The last family owner deeded 2.5 acres of land, the house and its contents, several outbuildings, a landscaped garden, and a small endowment to the Wyck Charitable Trust. The Wyck Charitable Trust and the Wyck Association now administer the preservation of the property and its educational services to the public. This collection contains diaries, letters, accounts, bills and receipts, deeds, and photographs. The collection as a whole is deepest for the period 1770-1970. Items of particular note include accounts of household expenses at Wyck from ca. 1790-1970; papers pertaining to the Academy of Natural Sciences of Philadelphia, Quaker schools, and social reform groups; agricultural and horticultural practices; and correspondence to and from cultural leaders of 18th and 19th century Philadelphia. The papers of the John S. Haines family (Ms. Coll. 52A) form part of the Wyck Papers. The papers cover the years 1845 to 1949 and are arranged into eight series.